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Affymetrix Pte Ltd - Microarray Systems, Genetic Research, Pharmaceuticals, Biotechnology Products, Ribonucleic Acid Extraction Kits 

 


Affymetrix Pte Ltd
Contact:
No. 7 Gul Circle
#2M-01/08. Keppel Logistics Building
Singapore 629563
Tel: (65) 6395-7200
Fax: (65) 6395-7300
E-mail: sales@affymetrix.com 
Website: www.affymetrix.com 
Categories: Microarray Systems, Genetic Research, Pharmaceuticals, Biotechnology Products, Ribonucleic Acid Extraction Kits
Company Profile: Affymetrix Inc manufactures products for genetic research including diagnostic tools and microarray systems for genome elucidation   
 
Affymetrix (AFFX) is a pioneer in creating breakthrough tools that are driving the genomic revolution. The vision, innovation, and devotion of Affymetrix employees help us empower scientists around the world to alleviate human suffering. It is not just the sheer power of GeneChip? technology that inspires us; it is the potential for it to help people.

Affymetrix Inc was one of the pioneering companies in genetic microarray technology in the 1980s. It now manufactures products for genetic research including diagnostic tools and microarray systems for genome elucidation. DNA microarrays are high-throughput technology used for research in molecular biology and medicine in identifying and measuring genetic information associated with complex diseases and testing potential drugs.

The technology involves devices with thousands of arrayed microscopic spots of DNA oligonucleotides, each containing picomoles of specific DNA sequence. The arrayed DNA sequences are used as probes to analyse cDNA or cRNA samples under highly stringent conditions. The hybridised probes are usually detected using fluorescence detection to give qualitative and quantitative results of nucleic acid sequences in the target sample (identification and quantification).

For the microarrays the DNA probes are covalently bonded to a solid surface using a chemical matrix (various silanes or polyacrylamide). The solid surface in the case of Affymetrix GeneChips is quartz glass (5in square chips).

Affymetrix quartz GeneChips using oligonucleotide microarrays are used for scanning for the presence of particular genes in biological samples. The microarrays are used on a single chip to carry out thousands of gene screening experiments in parallel.

In May 2007 Affymetrix opened its new manufacturing facility in Singapore. This is the company's first manufacturing facility located outside the US and has raised speculation about the company expanding to an area where the costs of manufacturing are much less.

March 2008 saw 23 job cuts at Sacramento and a statement about manufacturing transfer to Singapore being carried out in three phases (up to 40% of manufacturing volume). The consolidation is not expected to affect chemical reagent, instrument and logistics functions at the Sacramento plant, which was also expanded in 2006–2007.

Kevin King, president of life sciences business and executive vice president at Affymetrix, commented: "While Singapore offers a number of significant economic, political and lifestyle advantages, Affymetrix was most impressed with the country's commitment and support to the life sciences industry. In fact, a number of our most innovative and highly valued customers are here in Singapore, doing research in everything from cancer to population genetics to diabetes... This new facility enables us to better serve and support our growing customer base around the world."

The new Affymetrix Singapore facility is located at the Keppel Logistics Building at Gul Circle, Jurong Industrial Park. The facility has been operational since the end of 2006 and now employs 120 staff members. The facility was designed to look and operate like the company's main manufacturing facility in Sacramento.

"There are now more than 20 different molecular assay tests based on the Affymetrix platform under development by Affymetrix and its 11 PbA partners."Affymetrix has partnered with eleven different partners, powered by Affymetrix (PbA), to provide technology for diagnostic tests. One of the most recent agreements was with the French company Ipsogen for its Ipsogen MapQuant Dx Genomic Grade tumour grading test.

Tumour grade is one of the key indicators of malignancy and a more accurate measurement is a help to oncologists making decisions about treatment. Grade-3 tumours require chemotherapy, while grade-1 tumours are only treated with hormonotherapy. Traditional grading techniques show 50% of tumours classified in the intermediate grade-2 category, making treatment decisions problematic.

The MapQuant Dx Genomic Grade is a molecular test to grade breast carcinomas based on a 97-gene expression signature of the tumour. The use of this test provides a more precise and accurate grading measurement. There are now more than 20 different molecular assay tests based on the Affymetrix platform under development by Affymetrix and its 11 PbA partners.
 
     
     
 

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