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Singapore Cord Blood Bank Limited -
Biotechnology, Biotech Products,, Clinics, Hospitals,
Medical Facilities, Doctors, Health Services, Laboratories
Singapore Cord Blood Bank Limited
Contact:
Address: KK Women's & Children's Hospital, 100 Bukit Timah
Road, Women's Tower Basement 1, Unit OB60A
Singapore 168753
Tel: (65) 63945011 (65) 6394012
Fax: (65) 63945011 (65) 6394012
e-mail:
info@scbb.com.sg
Website:
www.scbb.com.sg Categories: Biotechnology, Biotech Products,,
Clinics, Hospitals, Medical Facilities, Doctors, Health
Services, Laboratories, Laboratory Equipment, Laboratory
Supplies Company Profile: Our mission is to provide cord blood
units of high safety and quality, through the practice of
internationally accredited techniques of collection,
processing, and banking, in order to support cord blood
transplantation in Singapore and around the world.
Processing & Cryopreservation of CBUs
The SCBB, as a Member of the National Marrow Donor
Program (NMDP) and American Association of Blood
Banks (AABB), had adopted and is in compliance with
the stringent international guidelines and
regulations for public cord blood banks.
The cycle starts as bags of collected cord blood are
transported to SCBB, processed, and preserved frozen
(< -150 °C) within 48 hours of being donated at one
of the participating hospitals. The collected
umbilical cord blood bags and related maternal blood
samples (blood samples from mother) are stored in a
temperature monitored environment during
transportation and before processing to ensure the
viability and integrity of the cells contained in
collected umbilical cord blood is preserved.
Stem cells are cells with the potential to develop
into many different cell types in the body during
their early life and growth. These stem cells serve
as an internal repair system in many tissues within
the body, dividing essentially without limit to
replenish other cells as long as the person is
alive.
Haematopoietic Stem Cells
The stem cells that form blood and immune cells are
known as haematopoietic stem cells (HSC). They are
responsible for the constant renewal of blood – the
production of billions of new blood cells each day.
Sources of Haematopoietic Stem Cells
HSCs are found in the bone marrow, peripheral blood
and umbilical cord blood. HSCs from these sources
are used to treat blood cancers and blood disorders.
Haematopoietic stem cell transplantation (HSCT),
otherwise known as blood stem cell transplantation,
is the process of giving a patient healthy HSCs to
help replace the blood stem cells that have been
affected by blood cancers or other blood disorders.
The stem cell donor and recipient must be Human
Leukocyte Antigen (HLA) compatible for a HSCT to be
successful. The donor cells will then be infused
into the recipient where it will travel to the bone
marrow to initiate blood cell production.
Cord Blood Cryopreservation
After the cord blood has been processed,
concentrated white blood cells are transferred to a
freezing bag and cryo-protectant will be added to
protect the cells during the cryopreservation
process. The freezing bag is placed in a protected
aluminum cassette case with a holding rack into the
Control Rate Freezer where the processed cord blood
unit is gradually frozen. The gradual freezing is to
protect the integrity of the stem cells and to
prevent it from damage.
When the cord blood unit (CBU) has reached the
optimum temperature of below -140°C, it will be
transferred to a cryopreservation storage tank in
vapour phase liquid nitrogen where the CBU will be
quarantined for a period of three to eight months.
During this quarantine period, a Nurse Coordinator
will follow-up with the mother about the baby and
the family to ensure that the medical condition has
not changed. During the same period, the maternal
infectious disease results, the cord blood’s
haematological tests and other test results will be
returned to the cord blood bank. If there are any
results that fall in SCBB’s exclusion criteria, the
CBU will be discarded or its status is re-assigned
either for Quality Assurance or Research.
If the CBU meets all the banking criteria after the
quarantine period, the CBU will be transferred to a
long-term storage cryopreservation tank where the
temperature is constantly maintained at less than
-150°C and continuously monitored via an alarm
system. This assures that the CBUs in SCBB are
closely monitored and are in compliance with
international regulations and quality standards.
Stem cells are cells with the potential to develop
into many different cell types in the body during
their early life and growth. These stem cells serve
as an internal repair system in many tissues within
the body, dividing essentially without limit to
replenish other cells as long as the person is
alive.
Haematopoietic Stem Cells
The stem cells that form blood and immune cells are
known as haematopoietic stem cells (HSC). They are
responsible for the constant renewal of blood – the
production of billions of new blood cells each day.
Sources of Haematopoietic Stem Cells
HSCs are found in the bone marrow, peripheral blood
and umbilical cord blood. HSCs from these sources
are used to treat blood cancers and blood disorders.
Haematopoietic stem cell transplantation (HSCT),
otherwise known as blood stem cell transplantation,
is the process of giving a patient healthy HSCs to
help replace the blood stem cells that have been
affected by blood cancers or other blood disorders.
The stem cell donor and recipient must be Human
Leukocyte Antigen (HLA) compatible for a HSCT to be
successful. The donor cells will then be infused
into the recipient where it will travel to the bone
marrow to initiate blood cell production.
Cord Blood Cryopreservation
After the cord blood has been processed,
concentrated white blood cells are transferred to a
freezing bag and cryo-protectant will be added to
protect the cells during the cryopreservation
process. The freezing bag is placed in a protected
aluminum cassette case with a holding rack into the
Control Rate Freezer where the processed cord blood
unit is gradually frozen. The gradual freezing is to
protect the integrity of the stem cells and to
prevent it from damage.
When the cord blood unit (CBU) has reached the
optimum temperature of below -140°C, it will be
transferred to a cryopreservation storage tank in
vapour phase liquid nitrogen where the CBU will be
quarantined for a period of three to eight months.
During this quarantine period, a Nurse Coordinator
will follow-up with the mother about the baby and
the family to ensure that the medical condition has
not changed. During the same period, the maternal
infectious disease results, the cord blood’s
haematological tests and other test results will be
returned to the cord blood bank. If there are any
results that fall in SCBB’s exclusion criteria, the
CBU will be discarded or its status is re-assigned
either for Quality Assurance or Research.
If the CBU meets all the banking criteria after the
quarantine period, the CBU will be transferred to a
long-term storage cryopreservation tank where the
temperature is constantly maintained at less than
-150°C and continuously monitored via an alarm
system. This assures that the CBUs in SCBB are
closely monitored and are in compliance with
international regulations and quality standards.
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