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Singapore Cord Blood Bank Limited - Biotechnology, Biotech Products,, Clinics, Hospitals, Medical Facilities, Doctors, Health Services, Laboratories

 


Singapore Cord Blood Bank Limited
Contact:
Address: KK Women's & Children's Hospital, 100 Bukit Timah Road, Women's Tower Basement 1, Unit OB60A
Singapore 168753
Tel: (65) 63945011 (65) 6394012
Fax: (65) 63945011 (65) 6394012
e-mail: info@scbb.com.sg 
Website: www.scbb.com.sg 
Categories: Biotechnology, Biotech Products,, Clinics, Hospitals, Medical Facilities, Doctors, Health Services, Laboratories, Laboratory Equipment, Laboratory Supplies
Company Profile: Our mission is to provide cord blood units of high safety and quality, through the practice of internationally accredited techniques of collection, processing, and banking, in order to support cord blood transplantation in Singapore and around the world.
 
Processing & Cryopreservation of CBUs
The SCBB, as a Member of the National Marrow Donor Program (NMDP) and American Association of Blood Banks (AABB), had adopted and is in compliance with the stringent international guidelines and regulations for public cord blood banks.

The cycle starts as bags of collected cord blood are transported to SCBB, processed, and preserved frozen (< -150 °C) within 48 hours of being donated at one of the participating hospitals. The collected umbilical cord blood bags and related maternal blood samples (blood samples from mother) are stored in a temperature monitored environment during transportation and before processing to ensure the viability and integrity of the cells contained in collected umbilical cord blood is preserved.

Stem cells are cells with the potential to develop into many different cell types in the body during their early life and growth. These stem cells serve as an internal repair system in many tissues within the body, dividing essentially without limit to replenish other cells as long as the person is alive.

Haematopoietic Stem Cells
The stem cells that form blood and immune cells are known as haematopoietic stem cells (HSC). They are responsible for the constant renewal of blood – the production of billions of new blood cells each day.

Sources of Haematopoietic Stem Cells
HSCs are found in the bone marrow, peripheral blood and umbilical cord blood. HSCs from these sources are used to treat blood cancers and blood disorders.

Haematopoietic stem cell transplantation (HSCT), otherwise known as blood stem cell transplantation, is the process of giving a patient healthy HSCs to help replace the blood stem cells that have been affected by blood cancers or other blood disorders. The stem cell donor and recipient must be Human Leukocyte Antigen (HLA) compatible for a HSCT to be successful. The donor cells will then be infused into the recipient where it will travel to the bone marrow to initiate blood cell production.

Cord Blood Cryopreservation
After the cord blood has been processed, concentrated white blood cells are transferred to a freezing bag and cryo-protectant will be added to protect the cells during the cryopreservation process. The freezing bag is placed in a protected aluminum cassette case with a holding rack into the Control Rate Freezer where the processed cord blood unit is gradually frozen. The gradual freezing is to protect the integrity of the stem cells and to prevent it from damage.

When the cord blood unit (CBU) has reached the optimum temperature of below -140°C, it will be transferred to a cryopreservation storage tank in vapour phase liquid nitrogen where the CBU will be quarantined for a period of three to eight months. During this quarantine period, a Nurse Coordinator will follow-up with the mother about the baby and the family to ensure that the medical condition has not changed. During the same period, the maternal infectious disease results, the cord blood’s haematological tests and other test results will be returned to the cord blood bank. If there are any results that fall in SCBB’s exclusion criteria, the CBU will be discarded or its status is re-assigned either for Quality Assurance or Research.

If the CBU meets all the banking criteria after the quarantine period, the CBU will be transferred to a long-term storage cryopreservation tank where the temperature is constantly maintained at less than -150°C and continuously monitored via an alarm system. This assures that the CBUs in SCBB are closely monitored and are in compliance with international regulations and quality standards.

Stem cells are cells with the potential to develop into many different cell types in the body during their early life and growth. These stem cells serve as an internal repair system in many tissues within the body, dividing essentially without limit to replenish other cells as long as the person is alive.

Haematopoietic Stem Cells
The stem cells that form blood and immune cells are known as haematopoietic stem cells (HSC). They are responsible for the constant renewal of blood – the production of billions of new blood cells each day.

Sources of Haematopoietic Stem Cells
HSCs are found in the bone marrow, peripheral blood and umbilical cord blood. HSCs from these sources are used to treat blood cancers and blood disorders.

Haematopoietic stem cell transplantation (HSCT), otherwise known as blood stem cell transplantation, is the process of giving a patient healthy HSCs to help replace the blood stem cells that have been affected by blood cancers or other blood disorders. The stem cell donor and recipient must be Human Leukocyte Antigen (HLA) compatible for a HSCT to be successful. The donor cells will then be infused into the recipient where it will travel to the bone marrow to initiate blood cell production.
Cord Blood Cryopreservation

After the cord blood has been processed, concentrated white blood cells are transferred to a freezing bag and cryo-protectant will be added to protect the cells during the cryopreservation process. The freezing bag is placed in a protected aluminum cassette case with a holding rack into the Control Rate Freezer where the processed cord blood unit is gradually frozen. The gradual freezing is to protect the integrity of the stem cells and to prevent it from damage.

When the cord blood unit (CBU) has reached the optimum temperature of below -140°C, it will be transferred to a cryopreservation storage tank in vapour phase liquid nitrogen where the CBU will be quarantined for a period of three to eight months. During this quarantine period, a Nurse Coordinator will follow-up with the mother about the baby and the family to ensure that the medical condition has not changed. During the same period, the maternal infectious disease results, the cord blood’s haematological tests and other test results will be returned to the cord blood bank. If there are any results that fall in SCBB’s exclusion criteria, the CBU will be discarded or its status is re-assigned either for Quality Assurance or Research.

If the CBU meets all the banking criteria after the quarantine period, the CBU will be transferred to a long-term storage cryopreservation tank where the temperature is constantly maintained at less than -150°C and continuously monitored via an alarm system. This assures that the CBUs in SCBB are closely monitored and are in compliance with international regulations and quality standards.
 
     
     
 

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